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105 genes with melanoma metastatic potential-specific expression
The expression of these genes is tied to the proliferative and invasive programs evoked by melanoma cells during disease progression. This gene list was first linked to metastatic potential by us (Hoek et al., 2006).
Motif 1 - expressed by proliferative phenotype melanoma cells
| Probe set | Gene symbol | Gene name |
| 206837_at | ALX1 | ALX homeobox 1 |
| 203300_x_at | AP1S2 | adaptor-related protein complex 1, sigma 2 subunit |
| 204416_x_at | APOC1 | apolipoprotein C-I |
| 203381_s_at 203382_s_at | APOE | apolipoprotein E |
| 221031_s_at | APOLD1 | apolipoprotein L domain containing 1 |
| 205681_at | BCL2A1 | BCL2-related protein A1 |
| 211890_x_at 214475_x_at 210944_s_at | CAPN3 | calpain 3, (p94) |
| 204995_at | CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| 207144_s_at | CITED1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 |
| 209235_at | CLCN7 | chloride channel 7 |
| 216513_at 216512_s_at 205337_at 205338_s_at | DCT | dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) |
| 204271_s_at 206701_x_at | EDNRB | endothelin receptor type B |
| 202454_s_at | ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
| 209570_s_at | FOXP1 | forkhead box P1 |
| 203397_s_at | GALNT3 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) |
| 217167_x_at | GK | glycerol kinase |
| 204187_at | GMPR | guanosine monophosphate reductase |
| 209169_at 209168_at 209170_s_at 209167_at | GPM6B | glycoprotein M6B |
| 206696_at | GPR143 | G protein-coupled receptor 143 |
| 206582_s_at 212070_at | GPR56 | G protein-coupled receptor 56 |
| 203632_s_at | GPRC5B | G protein-coupled receptor, family C, group 5, member B |
| 205862_at | GREB1 | growth regulation by estrogen in breast cancer 1 |
| 210964_s_at | GYG2 | glycogenin 2 |
| 205376_at | INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa |
| 204562_at | IRF4 | interferon regulatory factor 4 |
| 203723_at | ITPKB | inositol 1,4,5-trisphosphate 3-kinase B |
| 47550_at 219042_at | LZTS1 | leucine zipper, putative tumor suppressor 1 |
| 207323_s_at 209072_at | MBP | myelin basic protein |
| 207233_s_at | MITF | microphthalmia-associated transcription factor |
| 206426_at 206427_s_at | MLANA | melan-A |
| 219648_at | MREG | melanoregulin |
| 213638_at | PHACTR1 | phosphatase and actin regulator 1 |
| 207469_s_at | PIR | pirin (iron-binding nuclear protein) |
| 219584_at | PLA1A | phospholipase A1 member A |
| 210198_s_at | PLP1 | proteolipid protein 1 |
| 206470_at 213241_at | PLXNC1 | plexin C1 |
| 219412_at | RAB38 | RAB38, member RAS oncogene family |
| 206617_s_at | RENBP | renin binding protein |
| 210138_at | RGS20 | regulator of G-protein signaling 20 |
| 221524_s_at | RRAGD | Ras-related GTP binding D |
| 205334_at | S100A1 | S100 calcium binding protein A1 |
| 209848_s_at | SILV | silver homolog (mouse) |
| 221644_s_at 220245_at | SLC45A2 | solute carrier family 45, member 2 |
| 211546_x_at 207827_x_at 204466_s_at | SNCA | synuclein, alpha (non A4 component of amyloid precursor) |
| 209843_s_at | SOX10 | SRY (sex determining region Y)-box 10 |
| 213355_at 210942_s_at | ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
| 204653_at | TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| 209354_at | TNFRSF14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) |
| 206479_at | TRPM1 | transient receptor potential cation channel, subfamily M, member 1 |
| 206630_at | TYR | tyrosinase (oculocutaneous albinism IA) |
| 205694_at | TYRP1 | tyrosinase-related protein 1 |
Motif 2 - expressed by invasive phenotype melanoma cells
| Probe set | Gene symbol | Gene name |
| 208161_s_at | ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
| 213790_at 202952_s_at | ADAM12 | ADAM metallopeptidase domain 12 |
| 222108_at | AMIGO2 | adhesion molecule with Ig-like domain 2 |
| 202686_s_at | AXL | AXL receptor tyrosine kinase |
| 213905_x_at | BGN | biglycan |
| 204726_at | CDH13 | cadherin 13, H-cadherin (heart) |
| 203440_at | CDH2 | cadherin 2, type 1, N-cadherin (neuronal) |
| 212489_at 203325_s_at 212488_at | COL5A1 | collagen, type V, alpha 1 |
| 221541_at | CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 |
| 209101_at | CTGF | connective tissue growth factor |
| 209774_x_at | CXCL2 | chemokine (C-X-C motif) ligand 2 |
| 210764_s_at | CYR61 | cysteine-rich, angiogenic inducer, 61 |
| 204602_at | DKK1 | dickkopf homolog 1 (Xenopus laevis) |
| 214247_s_at | DKK3 | dickkopf homolog 3 (Xenopus laevis) |
| 218854_at | DSE | dermatan sulfate epimerase |
| 201983_s_at | EGFR | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) |
| 45297_at 221870_at | EHD2 | EH-domain containing 2 |
| 214446_at | ELL2 | elongation factor, RNA polymerase II, 2 |
| 204363_at | F3 | coagulation factor III (thromboplastin, tissue factor) |
| 202765_s_at 202766_s_at | FBN1 | fibrillin 1 |
| 204421_s_at 204422_s_at | FGF2 | fibroblast growth factor 2 (basic) |
| 206307_s_at | FOXD1 | forkhead box D1 |
| 219985_at | HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
| 205207_at | IL6 | interleukin 6 (interferon, beta 2) |
| 211506_s_at 202859_x_at | IL8 | interleukin 8 |
| 210511_s_at | INHBA | inhibin, beta A |
| 212942_s_at | KIAA1199 | KIAA1199 |
| 213640_s_at 215446_s_at 204298_s_at | LOX | lysyl oxidase |
| 202997_s_at 202998_s_at | LOXL2 | lysyl oxidase-like 2 |
| 212472_at 212473_s_at | MICAL2 | microtubule associated monoxygenase, calponin and LIM domain containing 2 |
| 204114_at | NID2 | nidogen 2 (osteonidogen) |
| 202238_s_at | NNMT | nicotinamide N-methyltransferase |
| 210510_s_at 212298_at | NRP1 | neuropilin 1 |
| 222020_s_at | NTM | neurotrimin |
| 204589_at | NUAK1 | NUAK family, SNF1-like kinase, 1 |
| 218718_at | PDGFC | platelet derived growth factor C |
| 202273_at | PDGFRB | platelet-derived growth factor receptor, beta polypeptide |
| 209318_x_at | PLAGL1 | pleiomorphic adenoma gene-like 1 |
| 201578_at | PODXL | podocalyxin-like |
| 207177_at | PTGFR | prostaglandin F receptor (FP) |
| 206157_at | PTX3 | pentraxin 3, long |
| 202628_s_at 202627_s_at | SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| 203438_at | STC2 | stanniocalcin 2 |
| 205547_s_at | TAGLN | transgelin |
| 222146_s_at 212387_at | TCF4 | transcription factor 4 |
| 201506_at | TGFBI | transforming growth factor, beta-induced, 68kDa |
| 201107_s_at 201110_s_at 201109_s_at 201108_s_at | THBS1 | thrombospondin 1 |
| 213869_x_at 208850_s_at 208851_s_at | THY1 | Thy-1 cell surface antigen |
| 204932_at 204933_s_at | TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b |
| 206117_at 206116_s_at 210986_s_at 210987_x_at | TPM1 | tropomyosin 1 (alpha) |
| 204083_s_at | TPM2 | tropomyosin 2 (beta) |
| 209946_at | VEGFC | vascular endothelial growth factor C |
| 205990_s_at | WNT5A | wingless-type MMTV integration site family, member 5A |
| 221029_s_at | WNT5B | wingless-type MMTV integration site family, member 5B |